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Hans A Kretzschmar Selected Research

Endopeptidase K (Proteinase K)

11/2007A refined method for molecular typing reveals that co-occurrence of PrP(Sc) types in Creutzfeldt-Jakob disease is not the rule.
8/2007Generation of genuine prion infectivity by serial PMCA.
8/2007A novel subtype of Creutzfeldt-Jakob disease characterized by a small 6 kDa PrP fragment.
12/2004Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage.
11/2002Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies.
3/2002Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases.

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Hans A Kretzschmar Research Topics

Disease

26Prion Diseases (Transmissible Spongiform Encephalopathies)
09/2013 - 03/2002
18Neoplasms (Cancer)
11/2015 - 03/2006
17Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
01/2014 - 02/2007
17Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease)
01/2012 - 05/2003
15Alzheimer Disease (Alzheimer's Disease)
12/2015 - 08/2003
15Scrapie
02/2014 - 11/2002
13Parkinson Disease (Parkinson's Disease)
01/2017 - 11/2002
13Neurodegenerative Diseases (Neurodegenerative Disease)
05/2011 - 11/2004
10Dementia (Dementias)
10/2015 - 08/2003
10Glioma (Gliomas)
01/2015 - 03/2006
9Frontotemporal Dementia (Semantic Dementia)
10/2015 - 10/2006
9Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
11/2012 - 10/2006
7Glioblastoma (Glioblastoma Multiforme)
11/2015 - 12/2007
6Sarcoma (Soft Tissue Sarcoma)
10/2015 - 11/2009
5Disease Progression
11/2015 - 06/2004
5Sporadic Creutzfeldt-Jakob Disease
09/2014 - 05/2003
5Acquired CJD
11/2008 - 11/2002
3Tauopathies
11/2015 - 06/2004
3Lewy Body Disease (Lewy Body Dementia)
10/2015 - 12/2004
3Medulloblastoma
02/2013 - 08/2011
3Infections
10/2011 - 09/2009
3Synucleinopathies
01/2011 - 11/2002
3Cognitive Dysfunction
08/2009 - 01/2007
2Brain Neoplasms (Brain Tumor)
02/2013 - 10/2012
2Ewing Sarcoma (Sarcoma, Ewing)
11/2012 - 09/2011
2TDP-43 Proteinopathies
02/2009 - 07/2007
2Motor Neuron Disease (Primary Lateral Sclerosis)
02/2009 - 07/2007
2Gliosis
01/2009 - 09/2006
2Nervous System Diseases (Neurological Disorders)
05/2008 - 01/2008
2Multiple System Atrophy
06/2004 - 06/2002
1Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis)
01/2014
1Fatal Familial Insomnia
08/2013
1Parkinsonian Disorders (Parkinsonism)
02/2013
1Anaplasia
10/2012

Drug/Important Bio-Agent (IBA)

32Prion ProteinsIBA
09/2014 - 03/2002
29Proteins (Proteins, Gene)FDA Link
10/2015 - 06/2004
10Biomarkers (Surrogate Marker)IBA
08/2014 - 11/2004
10PrionsIBA
08/2013 - 06/2005
9DNA-Binding Proteins (DNA Binding Protein)IBA
10/2015 - 02/2007
7alpha-SynucleinIBA
10/2008 - 06/2002
6Amyloid (Amyloid Fibrils)IBA
10/2015 - 04/2005
6ProgranulinsIBA
01/2014 - 03/2007
6UbiquitinIBA
01/2010 - 10/2006
6Endopeptidase K (Proteinase K)IBA
11/2007 - 03/2002
5Protein Isoforms (Isoforms)IBA
09/2013 - 06/2005
5DNA (Deoxyribonucleic Acid)IBA
11/2012 - 12/2007
5Codon (Codons)IBA
10/2012 - 11/2002
5AntibodiesIBA
02/2009 - 05/2003
4tau Proteins (tau Protein)IBA
01/2010 - 01/2005
414-3-3 Proteins (14-3-3 Protein)IBA
01/2010 - 09/2005
4Peptides (Polypeptides)IBA
08/2009 - 08/2003
4Laminin ReceptorsIBA
05/2009 - 01/2008
3Peptide Hydrolases (Proteases)FDA Link
10/2012 - 11/2007
3IntegrinsIBA
05/2012 - 07/2008
3Messenger RNA (mRNA)IBA
02/2011 - 08/2007
3RNA-Binding Protein FUSIBA
02/2011 - 11/2009
3Amyloid beta-PeptidesIBA
08/2009 - 08/2003
3Valosin Containing ProteinIBA
02/2009 - 02/2007
2Long Noncoding RNAIBA
01/2017 - 01/2015
25-hydroxymethylcytosineIBA
11/2015 - 10/2012
2EnzymesIBA
01/2015 - 01/2007
2CateninsIBA
02/2013 - 08/2011
2Biological ProductsIBA
12/2012 - 08/2007
2TATA-Box Binding Protein (TATA-Binding Protein)IBA
11/2012 - 09/2011
2Karyopherins (Importin)IBA
11/2012 - 09/2011
2RNA-Binding Proteins (RNA-Binding Protein)IBA
11/2012 - 09/2011
2Methionine (L-Methionine)FDA Link
10/2012 - 11/2002
2Protein AggregatesIBA
01/2012 - 11/2008
2SynucleinsIBA
12/2011 - 01/2011
2Temozolomide (Temodar)FDA LinkGeneric
04/2011 - 02/2011
2Alkylating AgentsIBA
02/2011 - 12/2007
2MethyltransferasesIBA
02/2011 - 12/2007
2Integrin beta3 (GPIIIa)IBA
12/2009 - 07/2008
2Integrin alphaVbeta3IBA
12/2009 - 07/2008
2alpha-internexinIBA
11/2009 - 07/2006
2CopperIBA
10/2009 - 01/2005
2S100 Calcium Binding Protein beta SubunitIBA
01/2009 - 01/2005
2Single-Chain AntibodiesIBA
08/2008 - 01/2008
2Fatty Acid Binding Protein 3IBA
01/2007 - 11/2004
1Presenilin-1IBA
12/2015
13- (1,3- benzodioxol- 5- yl)- 5- (3- bromophenyl)- 1H- pyrazoleIBA
11/2015
1GranulinsIBA
10/2015
1Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
10/2015
1DioxygenasesIBA
01/2015
1PiperazineIBA
02/2014
1lysosomal proteinsIBA
01/2014
1SaposinsIBA
01/2014
1Monoclonal AntibodiesIBA
12/2013
1SOXB1 Transcription FactorsIBA
06/2013
1DipeptidesIBA
03/2013
1Dihydroxyphenylalanine (Dopa)IBA
02/2013
1(18F)fluoroethyltyrosineIBA
12/2012
1Aldehyde DehydrogenaseIBA
11/2012
15-Methylcytosine (5 Methylcytosine)IBA
10/2012
1Valine (L-Valine)FDA Link
10/2012
1IsotopesIBA
10/2012
1benzamideIBA
08/2012
1Intergenic DNA (Junk DNA)IBA
07/2012

Therapy/Procedure

2Therapeutics
01/2012 - 12/2009
2Radiotherapy
04/2011 - 02/2011